Targeted inhibition of Botrytis cinerea laccases to minimise oxidative damage to wine
Research leads: Bragato Research Institute and Victoria University of Wellington
Botrytis cinerea, the fungus responsible for causing grey mould, can negatively impact wine quality by producing laccase enzymes that oxidise phenolic compounds. This enzymatic activity leads to browning, flavour loss, and spoilage, and ultimately a reduction in wine quality and loss of income. Current methods to control this unwanted oxidation face limitations related to regulation, health, and wine quality. This collaborative project between Victoria University of Wellington and Bragato Research Institute will apply cutting-edge genomics and protein-engineering tools to develop a precise, targeted intervention in order to protect premium wine quality.
The study will first explore the genetic diversity of B. cinerea strains found in New Zealand vineyards. Armed with knowledge of the diversity in laccases, advanced computational tools and biotechnological approaches will be used to characterise the properties of these enzymes and to design mini-proteins that specifically block their activity.